Discovery of a sexual cycle in Aspergillus clavatus

Discovery of a Sexual Cycle in Aspergillus lentulus, a Close Relative of A. fumigatus

Aspergillus lentulus was described in 2005 as a new species within the A. fumigatus sensu lato complex. It is an opportunistic human pathogen causing invasive aspergillosis with high mortality rates, and it has been isolated from clinical and environmental sources. The species is morphologically nearly identical to A. fumigatus sensu stricto, and this similarity has resulted in their frequent m...

Clavacin, an Antibiotic Substance from Aspergillus Clavatus*

In 1942 Wiesner (1) and Waksman, Horning, and Spencer (2) demonstrated that filtrates from cultures of Aspergillus clavatus grown upon synthetic media possess antibiotic activity. These investigators extracted and partially purified the active material (which was named clavacin by Waksman) but did not report its isolation in pure form. As a result of the observations made by Waksman’s group, pa...

Novel sexual-cycle-specific gene silencing in Aspergillus nidulans.

We report a novel sexual-cycle-specific gene-silencing system in the genetic model Aspergillus nidulans. Duplication of the mating type matA(HMG) gene in this haploid organism triggers Mat-induced silencing (MatIS) of both endogenous and transgenic matA genes, eliminates function of the encoded SRY structural ortholog, and results in formation of barren fruiting bodies. MatIS is spatiotemporall...

Two Novel Hepatocellular Carcinoma Cycle Inhibitory Cyclodepsipeptides from a Hydrothermal Vent Crab-Associated Fungus Aspergillus clavatus C2WU

Two novel cyclodepsipeptides containing an unusual anthranilic acid dimer and a D-phenyllactic acid residues, clavatustides A and B, were identified from cultured mycelia and broth of Aspergillus clavatus C2WU isolated from Xenograpsus testudinatus, which lives at extreme, toxic habitat around the sulphur-rich hydrothermal vents in Taiwan Kueishantao. This is the first example of cyclopeptides ...

Two Antagonistic Fungi, Aspergillus fumigatus and Aspergillus clavatus, and Their Antibiotic Substances.